New trends in synthesis of pyrazole nucleosides as new antimetabolites |
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| Authors: | Elgemeie Galal H Zaghary Wafaa A Amin Kamelia M Nasr Tamer M |
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| Institution: | Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, Cairo, Egypt. |
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| Abstract: | Pyrazole nucleosides and condensed pyrazole nucleosides exhibit various biological activities. This article describes recent synthetic approaches to their preparation, chemical properties, biological activities, and structure-activity relationships, with emphasis to selected drugs or drug candidates. Two pyrazole C-nucleoside compounds pyrazofurin (pyrazomycin) and its alpha-epimer pyrazofurin B are active components of potent antivirals approved for therapeutic use in human medicine aimed against various diseases caused by DNA viruses. |
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