Nicotinamide adenine dinucleotide (NAD) stimulation of DNA synthesis by human bone marrow cells. |
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Authors: | L P Schacter P J Burke |
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Institution: | 1. The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44106 USA;2. The Oncology Center, The Johns Hopkins School of Medicine, Baltimore, Maryland USA |
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Abstract: | Addition of 20 to 200 μg/ml of Nicotinamide Adenine Dinucleotide (NAD) to short term cultures of normal human bone marrow cells increases DNA synthesis only if human serum is present. Although NAD derivatives; reduced (NADH) and phosphorylated (NADP and NADPH) are equally effective, the components of NAD, Nicotinamide (NA) and Adenine (Ad) have no effect or reduce DNA synthesis at high concentrations. When malignant cells are tested; acute myeloblastic leukemia cell division is unaffected or reduced by NAD, NA or Ad. |
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