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Adaptogenic activity of a glyco-peptido-lipid fraction from the alcoholic extract of Trichopus zeylanicus Gaertn. |
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| Authors: | B Singh DK Gupta BK Chandan |
| Institution: | Department of Pharmacology, Regional Research Laboratory, Jammu-Tawi, India. rrlj@nde.vsnl.net.in |
| Abstract: | A glyco-peptido lipid fraction ("AF") from the alcoholic extract of Trichopus zeylanicus Gaertn. was evaluated for putative antistress activity in a battery of tests. "AF" exhibited significant antistress activity in dose dependent manner in all the parameters studied, against the different stresses use to induce non-specific stress. Ashwagandha, the commercial extract of Withania somnifera roots was used as control: A preliminary acute toxicity study in mice showed a good margin of safety, as the ALD50 value was more than 3000 mg/kg body wt. p.o. with no signs of abnormalities. |
| Keywords: | Trichopus zeylannnicus adaptogens antifatigue antistress gastric ulcertation hypoxia SNIR (nonspecific increase of resistance of the organism) immuno-stimulant swimming endurance Withania somnifera inflammation carrageenan |
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