New structural and functional defects in polyphosphate deficient bacteria: A cellular and proteomic study |
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| Authors: | Cristian Varela Cecilia Mauriaca Alberto Paradela Juan P Albar Carlos A Jerez Francisco P Chávez |
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| Institution: | 1.Laboratory of Molecular Microbiology and Biotechnology & Millennium Institute of Cell Dynamics and Biotechnology (ICDB), Department of Biology,Faculty of Sciences, University of Chile,?u?oa,Chile;2.Servicio de Proteómica,Centro Nacional de Biotecnología,Madrid,Espa?a |
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| Abstract: | Background Inorganic polyphosphate (polyP), a polymer of tens or hundreds of phosphate residues linked by ATP-like bonds, is found in
all organisms and performs a wide variety of functions. PolyP is synthesized in bacterial cells by the actions of polyphosphate
kinases (PPK1 and PPK2) and degraded by exopolyphosphatase (PPX). Bacterial cells with polyP deficiencies due to knocking
out the ppk1 gene are affected in many structural and important cellular functions such as motility, quorum sensing, biofilm formation
and virulence among others. The cause of this pleiotropy is not entirely understood. |
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