Calmodulin-like activity in the soluble fraction of Escherichia coli |
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Authors: | Y Iwasa K Yonemitsu K Matsui K Fukunaga E Miyamoto |
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Institution: | Department of Pharmacology Kumamoto University Medical School, Kumamoto 860, Japan |
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Abstract: | A heat-stable factor with properties similar to those of calmodulin was found in the fraction containing Ca2+-dependent cyclic AMP phosphodiesterase of . The factor activated such enzymes as cyclic nucleotide phosphodiesterase of bovine brain, (Ca2+,Mg2+)ATPase of human erythrocyte menbrane and myosin light chain kinase of rabbit myometrium in a Ca2+-dependent fashion with an apparent Ka of 5 × 10?5. The factor and brain calmodulin had no effect on the phosphodiesterase of . It may be concluded that calmodulin or a calmodulin-like protein occurs in prokaryotes. |
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