| 自噬的调控通路和肿瘤 |
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| 引用本文： | 张秀春,李丹妮,李丰. 自噬的调控通路和肿瘤[J]. 生命科学, 2011, 0(1): 19-25 |
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| 作者姓名： | 张秀春 李丹妮 李丰 |
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| 作者单位： | 中国医科大学临床医药学院;中国医科大学基础医学院细胞生物学教研室卫生部细胞生物学重点实验室暨教育部医学细胞生物学重点实验室; |
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| 基金项目： | 国家自然科学基金项目(30771128,90813038); 国家高技术发展计划“(863”计划)(2007AA02Z305); 辽宁省教育厅创新团队项目(20087195) |
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| 摘 要： | 自噬是指胞浆内大分子物质和细胞器在膜包囊泡中大量降解的生物学过程,其具有独特的分子机制、形态改变和特有的调控通路,作为各种调控通路交汇点——mTOR复合体和Beclin1复合体发挥了至关重要的作用。对于人体而言,自噬具有维持细胞自我稳态,促进细胞生存的作用,然而,过度自噬则可以引起细胞死亡即＂自噬性细胞死亡＂。相关研究表明,自噬的这种特点与肿瘤的发生密切相关。对于肿瘤,自噬作用好似一把双刃剑,既促进其发生又抑制其形成。
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| 关 键 词： | 自噬 mTOR Beclin1 肿瘤 |
A regulatory pathway of autophagy and tumor |
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| ZHANG Xiu-Chun ,LI Dan-Ni,LI Feng. A regulatory pathway of autophagy and tumor[J]. Chinese Bulletin of Life Sciences, 2011, 0(1): 19-25 |
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| Authors: | ZHANG Xiu-Chun LI Dan-Ni LI Feng |
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| Affiliation: | ZHANG Xiu-Chun 1,LI Dan-Ni,LI Feng 2*(1 College of Clinical Medicine,China Medical University,Shenyang 110001,China,2 Key Laboratory of Cell Biology of Ministry of Public Health and Key Laboratory of Medical Cell Biology of Ministry of Education,Department of Cell Biology,College of Basic Medical Science,China) |
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| Abstract: | Autophagy is a process of self-degradation of cellular components,in which double-membrane autophagosome sequester organelles or portions of cytosol and fuse with lysosomes for breakdown.It has the unique morphological changes and specific regulatory pathways.As the convergences of various pathways,mTOR complex and Beclin1 complex play a crucial role in the regulation of autophagy.On the one hand,autophagy maintains cell homeostasis by elimating damaged organelles,as well as removing misfolded or aggregated... |
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| Keywords: | autophagy mTOR Beclin1 tumor |
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