| 急性期应答与胆固醇逆向转运 |
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| 引用本文： | 汤石林,唐朝克.急性期应答与胆固醇逆向转运[J].生命的化学,2011(3). |
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| 作者姓名： | 汤石林 唐朝克 |
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| 作者单位： | 南华大学心血管病研究所动脉硬化学湖南省重点实验室生命科学研究中心;南华大学附一医院ICU; |
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| 基金项目： | 国家自然科学基金资助项目(81070220); 湖南省自然科学衡阳联合基金资助项目(10JJ9019); 衡阳市科技局资金资助项目(2010kj41)资助 |
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| 摘 要： | 胆固醇逆向转运(reverse cholesterol transport,RCT)是促进外周胆固醇从细胞内流出,然后转运到肝脏进行代谢的过程,是机体抗动脉粥样硬化相关疾病的重要机制。研究表明,感染、炎症及创伤等诱导的急性期应答(acute phase response,APR)影响高密度脂蛋白的结构和功能,抑制细胞内胆固醇流出、血浆胆固醇转运及肝脏胆固醇代谢和排泌等环节,因此抑制体内RCT。APR短期抑制RCT有利于机体抗感染和组织损伤,然而,APR对RCT的进一步抑制将促进外周组织胆固醇蓄积及代谢紊乱,可能是多种感染免疫性疾病、代谢性疾病与动脉粥样硬化呈正相关的关键因素。本文就APR调节机体RCT的最新研究进展作一综述。
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| 关 键 词： | 急性期应答 胆固醇逆向转运 动脉粥样硬化 脂多糖 高密度脂蛋白 |
The relationship between acute phase response and reverse cholesterol transport |
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| TANG Shilin,TANG ChaokeInstitute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,Life Science Research Center,Hengyang ,China,Intensive,Care Unit of the First Affiliated Hosipal,University of South China Hengyang.The relationship between acute phase response and reverse cholesterol transport[J].Chemistry of Life,2011(3). |
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| Authors: | TANG Shilin TANG ChaokeInstitute of Cardiovascular Disease Key Laboratory for Atherosclerology of Hunan Province Life Science Research Center Hengyang China Intensive Care Unit of the First Affiliated Hosipal University of South China Hengyang |
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| Institution: | TANG Shilin1,2,TANG Chaoke11Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,Life Science Research Center,Hengyang 421001,China,2Intensive,Care Unit of the First Affiliated Hosipal,University of South China Hengyang 421001 |
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| Abstract: | Reverse cholesterol transport(RCT),the process during which accumulated cholesterol is transported from the vessel wall to the liver for excretion,is an important mechanism of preventing atherosclerosis-related diseases.Recent studies have shown that infection,inflammation and trauma-induced acute phase response(APR) can affect the structure and function of high density lipoprotein,and inhibit cellular cholesterol efflux,plasma cholesterol transport and hepatic cholesterol metabolism,therefore inhibiting th... |
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| Keywords: | acute phase reaction reverse cholesterol transport atherosclerosis lipopolysaccharide high-density lipoprotein |
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