鞘糖脂研究进展

鞘糖脂位于细胞膜脂质双分子层,是哺乳动物细胞膜上的必需组成成分之一,参与细胞的多种生物学活动,其生物学功能非常复杂。在免疫应答、细胞发育、细胞识别及分化中都发挥重要的作用。组织器官中鞘糖脂的异常表达往往与各种疾病具有明显的相关性。因此鞘糖脂的结构表征、构效关系研究以及与之相关的鞘糖脂生物合成及分解代谢途径的研究已成为近年来的热点问题。最近研究也表明鞘糖脂在疾病的发生发展及治疗过程中都具有至关重要的作用。对鞘糖脂的结构与功能的关系、糖脂的合成代谢以及糖脂的分离分析方法作一综述。

Progress in study of glycosphingolipids

Glycosphingolipids locate in the bilayer lipid membrane.They are important compositions of the mem-brane of mammals.Their biological function is very complex.They play important roles in the immune response,cell growth,cell recognition,differentiation,etc.The abnormal expressions of glycosphingolipids in various tissues often have obvious associations with diverse diseases.Therefore,structure characterization,QSAR studies,biosyn-thesis and catabolic pathways of glycosphingolipids have become hot issues in r...