| 硫氧还蛋白的结构及在生物抗氧化中的功能 |
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| 引用本文： | 马宇光,杨帆,杨卫军. 硫氧还蛋白的结构及在生物抗氧化中的功能[J]. 生命的化学, 2011, 0(3) |
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| 作者姓名： | 马宇光 杨帆 杨卫军 |
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| 作者单位： | 浙江大学生命科学学院细胞与发育生物学研究所; |
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| 基金项目： | 浙江省科技厅资助项目(2008C02G2010021); 国家自然科学基金项目(30901093)资助 |
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| 摘 要： | 硫氧还蛋白(thioredoxin,Trx)是广泛存在于原核与真核生物体内的氧化还原调节蛋白。Trx通过对目标蛋白质进行还原,从而调节机体的氧化还原平衡。Trx与硫氧还蛋白还原酶(thioredoxin reductase,TrxR)及NADPH共同组成硫氧还蛋白系统参与众多生理过程。细胞中的活性氧是导致生物氧化胁迫的一个主要方面。Trx可以通过对细胞内被氧化的二硫键的还原来修复机体的氧化损伤,并通过这种方式防止机体衰老。同时,Trx系统可以与其它氧化还原系统如谷胱甘肽(GSH)系统协调配合,并消除体内过多的活性氧。
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| 关 键 词： | 硫氧还蛋白 氧化胁迫 活性氧 |
The structure of thioredoxin and its role in the biological resistance of oxidation stress |
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| MA Yuguang,YANG Fan,YANG Weijun Institute of Cell , Development Biology,College of Life Science,Zhejiang University,Hangzhou,,China. The structure of thioredoxin and its role in the biological resistance of oxidation stress[J]. Chemistry of Life, 2011, 0(3) |
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| Authors: | MA Yuguang YANG Fan YANG Weijun Institute of Cell Development Biology College of Life Science Zhejiang University Hangzhou China |
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| Affiliation: | MA Yuguang,YANG Fan,YANG Weijun Institute of Cell and Development Biology,College of Life Science,Zhejiang University,Hangzhou,310058,China |
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| Abstract: | Thioredoxin is a ubiquitous redox-regulatory protein present in prokaryotic and eukaryotic organisms.Thioredoxin reduces target protein and therefore regulates redox balance in organism.Thioredoxin,thioredoxin reductase and NADPH together constitute the Trx system and play a role in numerous physiological processes.Reactive oxygen species in cell is a major aspect leading to biological oxidative stress.Thioredoxin cures organisms in oxidative damage by reducing oxidated disulfide bonds in cell and also prev... |
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| Keywords: | Thioredoxin oxidative stress ROS |
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