| 白桦脂酸的研究进展 |
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| 引用本文： | 徐军,王晋萍,钱辰旭,仇文卫,杨帆,汤杰.白桦脂酸的研究进展[J].生命科学,2011(5):503-510. |
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| 作者姓名： | 徐军 王晋萍 钱辰旭 仇文卫 杨帆 汤杰 |
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| 作者单位： | 华东师范大学化学系药物化学研究所; |
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| 基金项目： | 国家自然科学基金项目(20802020) |
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| 摘 要： | 白桦脂酸是一种五环三萜酸,存在于多种天然植物,特别是白桦树皮中,毒性低,安全指数高。近年来发现白桦脂酸具有抗肿瘤、抗HIV、抗炎、抗菌、抗疟疾等多种生物活性,特别是在抗黑色素瘤与抗HIV方面具有突出的表现,从而引起了人们极大的研究兴趣。对白桦脂酸的来源和生物活性进行了简要综述。
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| 关 键 词： | 白桦脂酸 白桦脂酸制备 生物活性 肿瘤 抗HIV |
Progress of study on betulinic acid |
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| XU Jun,WANG Jin-Ping,QIAN Chen-Xu,QIU Wen-Wei,YANG Fan,TANG Jie.Progress of study on betulinic acid[J].Chinese Bulletin of Life Sciences,2011(5):503-510. |
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| Authors: | XU Jun WANG Jin-Ping QIAN Chen-Xu QIU Wen-Wei YANG Fan TANG Jie |
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| Institution: | XU Jun,WANG Jin-Ping,QIAN Chen-Xu,QIU Wen-Wei*,YANG Fan,TANG Jie(Institute of Medicinal Chemistry,Department of Chemistry,East China Normal University,Shanghai 200062,China) |
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| Abstract: | The betulinic acid(BA),a type of pentacyclic triterpene acid,which is found in the bark of several species of plants,principally the white birch.It has a variety of biological activities,such as anti-tumor,anti-HIV,anti-inflammatory,antimicrobial,and antimalarial activity,especially in anti-melanoma and anti-HIV show great promise.In this paper,the preparation and bioactivities of betulinic acid are reviewed. |
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| Keywords: | betulinic acid preparation of betulinic acid biological activity tumor anti-HIV |
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