| 新型糖基化酶AlkC和AlkD |
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| 引用本文： | 魏建科,关文,朱静,曹春阳,龚福春. 新型糖基化酶AlkC和AlkD[J]. 生命的化学, 2011, 0(3) |
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| 作者姓名： | 魏建科 关文 朱静 曹春阳 龚福春 |
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| 作者单位： | 长沙理工大学化学与生物工程学院;中国科学院上海有机化学研究所; |
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| 基金项目： | 国家自然科学基金项目(20902103;20872169和20921091); 上海市浦江计划人才项目(08PJ1411700); 科技部重大研究计划项目(2009CB918600)资助 |
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| 摘 要： | DNA糖基化酶是一类有着重要生物功能的蛋白质,广泛存在于原核生物和真核生物中。研究表明,DNA糖基化酶能够特异性地识别损伤碱基,再通过各种酶修复DNA。最近,科学家在筛选土壤中3-甲基腺嘌呤糖基化酶时,发现了三种基因AlkC、AlkD和AlkE,其中AlkC和AlkD是两种新基因。本文根据近年来的研究成果,对AlkC和AlkD两种碱基糖基化修复酶的结构和功能,以及AlkD的切除损伤DNA的核酸捕获机理进行了总结。
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| 关 键 词： | DNA糖基化酶 AlkC AlkD |
Research progress of two novel DNA glycosylases:AlkC and AlkD |
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| WEI Jianke,,GUAN Wen,ZHU Jing,CAO Chunyang,GONG FuchunCollege of chemistry , Biological Engineering,Changsha University of Science , Technology,Changsha ,China. Research progress of two novel DNA glycosylases:AlkC and AlkD[J]. Chemistry of Life, 2011, 0(3) |
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| Authors: | WEI Jianke GUAN Wen ZHU Jing CAO Chunyang GONG FuchunCollege of chemistry Biological Engineering Changsha University of Science Technology Changsha China |
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| Affiliation: | WEI Jianke1,2,GUAN Wen2,ZHU Jing2,CAO Chunyang2,GONG Fuchun11College of chemistry and Biological Engineering,Changsha University of Science and Technology,Changsha 410114,China,2Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 |
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| Abstract: | Existing in prokaryotes and eukaryotes,DNA glycosylase is a kind of protein which has very important biological functions.They can recognize specific lesion bases in DNA and repair it by hydrolyzing C-N glycosidic bond of the damaged site in DNA.Recently scientists have discovered three genes,AlkC,AlkD and AlkE during screening 3-methyladenine DNA glycosylase in genomic libraries of the soil bacterium.Among them,AlkC and AlkD were discovered for the first time.In this paper,a detailed review on the research... |
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| Keywords: | DNA glycosylase AlkC AlkD |
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