| 五羟色胺转运体的研究进展 |
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| 引用本文： | 范东芬,奚耕思,梁开丹,张武会.五羟色胺转运体的研究进展[J].生命科学,2011(4):385-389. |
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| 作者姓名： | 范东芬 奚耕思 梁开丹 张武会 |
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| 作者单位： | 陕西师范大学生命科学学院动物生殖与发育实验室; |
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| 基金项目： | 陕西省农业攻关项目(2008K02-10) |
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| 摘 要： | 五羟色胺转运体是一种对五羟色胺（5-HT,serotonin）有高度亲和力的跨膜转运蛋白,能够重新摄取细胞间隙内的5-HT,从而调节神经信号的转导。该文简述了五羟色胺转运体的生物学特性、分布以及与人类疾病的关系,通过分析比较发现,五羟色胺转运体的多态性与肠易激综合征、抑郁症、强迫症都有着密切的关系。
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| 关 键 词： | 五羟色胺 五羟色胺转运体 基因多态性 抑郁症 |
Serotonin transporter progress |
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| FAN Dong-Fen,XI Geng-Si,LIANG Kai-Dan,ZHANG Wu-Hui.Serotonin transporter progress[J].Chinese Bulletin of Life Sciences,2011(4):385-389. |
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| Authors: | FAN Dong-Fen XI Geng-Si LIANG Kai-Dan ZHANG Wu-Hui |
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| Institution: | FAN Dong-Fen,XI Geng-Si*,LIANG Kai-Dan,ZHANG Wu-Hui(College of Life Science,Shaanxi Normal University,Xi'an 710062,China) |
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| Abstract: | 5-Hydroxytamine transporter(SERT) is a kind of transmembrane transporter that has high affinity with 5-HT and can intake 5-HT in the intercellular space.Then SERT can regulate the transduction of neuronal signals.This paper illustrated the bionomics and distribution of SERT,and the relation to the diseases of human.Many investigation found that the polymorphism of the SERT may be related to irritable bowel syndrome,depression and obsessive compulsive disorder. |
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| Keywords: | serotonin serotonin transporter gene polymorphism depression |
| 本文献已被 CNKI 维普 等数据库收录！ |
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