| 基因突变在结直肠癌发生机制中的作用:殊途同归 |
| |
| 引用本文： | 晏群,马健. 基因突变在结直肠癌发生机制中的作用:殊途同归[J]. 生命的化学, 2011, 0(3) |
| |
| 作者姓名： | 晏群 马健 |
| |
| 作者单位： | 中南大学湘雅医院检验科;中南大学肿瘤研究所;中南大学疾病基因组研究中心; |
| |
| 基金项目： | 国家自然科学基金项目(81071756)资助 |
| |
| 摘 要： | 结直肠癌的多步骤演进模式一直是肿瘤研究的经典,在这一过程中,序贯发生的基因突变(或其它遗传事件)是重要的推动力。本文综述了在结直肠癌中检测到的基因突变情况,并分析了在新一代测序技术的带动下,结直肠癌基因组学的最新进展。结直肠癌组织基因突变的地形图理念对于今后的肿瘤分子诊疗将具有重要意义。肿瘤不仅是基因病,更是信号通路异常病。
|
| 关 键 词： | 结直肠癌 基因突变 信号传送通路 基因组学 |
Role of genes mutation in the colorectal carcinogenesis:all roads lead to Rome |
| |
| YAN Qun,MA Jian, Clinical laboratory of Xiang-Ya Hospital,Central South University,Changsha ,China,Cancer Research Institute,Changsha ,Research Center for Disease Genome. Role of genes mutation in the colorectal carcinogenesis:all roads lead to Rome[J]. Chemistry of Life, 2011, 0(3) |
| |
| Authors: | YAN Qun MA Jian Clinical laboratory of Xiang-Ya Hospital Central South University Changsha China Cancer Research Institute Changsha Research Center for Disease Genome |
| |
| Affiliation: | YAN Qun1,MA Jian2,3 1Clinical laboratory of Xiang-Ya Hospital,Central South University,Changsha 410008,China,2Cancer Research Institute,Changsha 410078,3Research Center for Disease Genome |
| |
| Abstract: | The multi-step model of carcinogenesis is now widely accepted for colorectal cancer.Sequential steps of genes mutation(or other genetic hits) are the drivers of this process.This review focuses on the gene mutation detected in the colorectal cancer and analyzes the recent advancement in colorectal cancer genome research at the cutting edge of next-generation sequencing technology.The gene mutation landscape of colorectal cancer is a promising concept for molecular cancer therapy.Cancer is not only a gene di... |
| |
| Keywords: | colorectal cancer gene mutation signaling pathway genomics |
| 本文献已被 CNKI 等数据库收录！ |
|
