| Hedgehog信号通路与肿瘤 |
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| 引用本文： | 王琪琳,苏玲,刘相国. Hedgehog信号通路与肿瘤[J]. 生命的化学, 2011, 0(1) |
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| 作者姓名： | 王琪琳 苏玲 刘相国 |
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| 作者单位： | 山东大学生命科学学院;聊城大学生命科学学院; |
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| 基金项目： | 山东省博士基金(BS2009YY004); 山东省科学技术发展计划(2010GSF10218)资助 |
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| 摘 要： | Hedgehog信号通路在胚胎发育中细胞的生长分化、组织器官形成以及成体干细胞的维持和自稳态的保持等方面具有重要作用。同时,Hedgehog信号通路与Wnt信号通路、Notch信号通路等相互作用、密切联系,在肿瘤的发生、发展过程中也起到关键作用。论文综述了Hedgehog信号通路的作用机理,与其他信号通路、蛋白质因子的相互联系,以及在肿瘤研究中所关注的靶位点和小分子化合物抑制剂,对于癌症的预防和治疗具有一定的参考价值。
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| 关 键 词： | Hedgehog(Hh)信号通路 Gli转录因子 肿瘤治疗 上皮细胞-间充质细胞转换(EMT) 环帕明 |
Relationship between Hedgehog signaling pathway and related tumors |
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| WANG Qilin,,SU Ling,LIU Xiangguo School of Life Science,Sh,ong University,Jinan ,China,School of Life Science,Liaocheng University,Liaocheng. Relationship between Hedgehog signaling pathway and related tumors[J]. Chemistry of Life, 2011, 0(1) |
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| Authors: | WANG Qilin SU Ling LIU Xiangguo School of Life Science Sh ong University Jinan China School of Life Science Liaocheng University Liaocheng |
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| Affiliation: | WANG Qilin1,2,SU Ling1,LIU Xiangguo1 1School of Life Science,Shandong University,Jinan 250100,China,2School of Life Science,Liaocheng University,Liaocheng 252059 |
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| Abstract: | Hedgehog signaling plays an essential role in embryonic differentiation, pattern formation and adult cell homeostasis. Simultaneously hedgehog signaling has closd correlation with Wnt signaling and Notch signaling, and plays a critical role in tumor initiation and progression. This review focuses on the regulatory mechanism and physiological functions of Hedgehog signaling, and the relationship with other signaling pathways and protein factors. The target sites and small molecular inhibitors in tumor have a... |
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