| 生物节律基因period3的研究进展 |
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| 引用本文： | 安怀杰,俞炜源,赵晓航.生物节律基因period3的研究进展[J].生命科学,2011(5):465-469. |
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| 作者姓名： | 安怀杰 俞炜源 赵晓航 |
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| 作者单位： | 海军总医院全军航海航空医学中心;军事医学科学院生物工程研究所; |
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| 基金项目： | 国家自然科学基金项目(30721001,30973373); 海后司令部科研计划课题(HBJ09JD11) |
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| 摘 要： | 昼夜节律是所有真核生物和部分原核生物的基本特征,一组节律表达的生物钟基因形成24 h周期振荡的自主调节转录-翻译反馈回路。period（per）基因家族是生物钟反馈回路中重要组成成分,per3基因是period基因家族成员之一。人类的per3基因定位于染色体1p36,其编码区第18外显子中含有一个灵长类特有的串联重复序列（variable number tandem repeat,VNTR）。该VNTR包含一簇理论上的磷酸化位点,能影响PER3蛋白的磷酸化降解,影响PER3蛋白的功能。近年研究发现,per3基因多态性与睡眠结构、睡眠紊乱发病年龄、睡眠剥夺后次日清晨执行能力等密切相关。
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| 关 键 词： | 昼夜节律 钟基因 period3基因 串联重复多态性 |
Research advances of circadian rhythms gene period3 |
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| AN Huai-Jie,YU Wei-Yuan,ZHAO Xiao-Hang.Research advances of circadian rhythms gene period3[J].Chinese Bulletin of Life Sciences,2011(5):465-469. |
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| Authors: | AN Huai-Jie YU Wei-Yuan ZHAO Xiao-Hang |
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| Institution: | AN Huai-Jie1,YU Wei-Yuan2,ZHAO Xiao-Hang1*(1 Medical Center of Navigation & Aviation of PLA,Navy General Hospital,Beijing 100037,China,2 Institute of Bioengineering,Academy of Military Medical Sciences,Beijing 100071,China) |
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| Abstract: | Circadian rhythms represent a type of cellular regulation common to eukaryotes and some of the prokaryotes.Circadian oscillations are cell autonomous.They operate through a negative feedback loop and a set of genes has been discovered as the genetic basis of this phenomenon.Period(per) gene family is an important component of the 24 h cycle.Among these per family clock genes,per3,located in 1p36,is of special interest since it contains a variable number of tandem repeats(VNTR) polymorphism in the coding reg... |
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| Keywords: | circadian rhythm clock gene period3 gene variable number tandem repeat polymorphism(VNTR) |
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