| 钙蛋白酶与心血管疾病的关系 |
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| 引用本文： | 吴金兰,万福生. 钙蛋白酶与心血管疾病的关系[J]. 生命的化学, 2011, 0(1) |
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| 作者姓名： | 吴金兰 万福生 |
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| 作者单位： | 南昌大学基础医学院生物化学与分子生物学教研室; |
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| 基金项目： | 江西省自然基金资助项目(No.0540035)资助 |
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| 摘 要： | 钙蛋白酶(calpain)是一种依赖Ca2+激活的蛋白水解酶,属于半胱氨酸蛋白水解酶超家族成员。钙蛋白酶广泛分布于心血管系统,可被Ca2+激活,产生多种生物学效应,如降解心肌收缩蛋白、促进细胞凋亡、参与心血管重构等。近年,钙蛋白酶与心肌缺血再灌注损伤、血栓、房颤、动脉粥样硬化等心血管疾病的关系正受到越来越多的关注。
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| 关 键 词： | 钙蛋白酶 心血管系统 血栓 凋亡 |
Roles of calpains in cardiovascular system diseases |
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| WU Jinlan,WAN Fusheng. Roles of calpains in cardiovascular system diseases[J]. Chemistry of Life, 2011, 0(1) |
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| Authors: | WU Jinlan WAN Fusheng |
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| Affiliation: | WU Jinlan,WAN Fusheng Department of Biochemistry and Molecular Biology,Basic Medical College of Nanchang University,Nanchang 330006,China |
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| Abstract: | Calpain is a Ca2+-activated protease, which belongs to the super family of homocystein protease. Upon activation, calpains can cleave myocardial contractile protein, promote myocardial apoptosis, be involved in cardiovascular remodeling, and so on. The relationship between calpains and cardiovascular system diseases such as ischemia reperfusion injury, thrombosis, atrial fibrillation, atherosclerosis, etc, has received more and more attention in recent years. |
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| Keywords: | calpain cardiovascular system thrombosis apoptosis |
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