Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors. |
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| Authors: | L Zhang M A Williams D B Mendel P A Escarpe X Chen K Y Wang B J Graves G Lawton C U Kim |
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| Institution: | Gilead Sciences Inc., Foster City, CA 94404, USA. |
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| Abstract: | 1,4,5,6-Tetrahydropyridazine derivative 15 and its C-5 epimer 19, which possessed side chains similar to GS4071, were synthesized via a hetero Diels-Alder reaction, and evaluated as influenza neuraminidase inhibitors. Compounds 15 and 19 exhibited a microM range of influenza neuraminidase inhibitory activity. |
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