Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro |
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| Authors: | Tang Yan-bo Peng Zong-gen Liu Zong-ying Li Yan-ping Jiang Jian-dong Li Zhuo-rong |
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| Affiliation: | Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China. |
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| Abstract: | A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent antiviral agents. The antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent antiviral activities. The IC(50) of 5f for HBV was 2.15 microM, and the IC(50) of 5g for HIV-1 was 1.61 microM. |
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