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Synthesis and biological properties of 6-oxa-D-homo-8alpha analogues of steroid estrogens |
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| Authors: | Shavva A G Morozkina S N Ishchenko I V Eliseev I I Selivanov S I Abusalimov Sh N Selivanov S S Kameneva I Iu Eshchenko N D |
| Abstract: | Modifications of 6-oxa-D-homo-8alpha-analogues of steroid estrogens were found to lead to a complete loss of the uterotropic and hypertriglyceridemic activities. These compounds may be promising for the design on their basis of inhibitors of the steroid hormone metabolism and transporters of other compounds to the estrogen target organs. |
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