Expression of CA IX in dysplasia adjacent to surgical resection margins of oral squamous cell carcinoma |
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| Authors: | M Pérez-Sayáns JM Suárez-Peñaranda M Torres-López CT Supuran P Gándara-Vila P Gayoso-Diz |
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| Affiliation: | 1. Oral Medicine, Oral Surgery and Implantology Unit, Faculty of Medicine and Dentistry, Institute of Sanitary Research of Santiago, (IDIS),Entrerrios s/n, Santiago de Compostela C.P. 15782;2. Department of Pathology and Forensic Sciences, University Hospital and School of Medicine of Santiago de Compostela, Pathological Service of University Clinic Hospital of Santiago de Compostela;3. Bioorganic Chemistry Laboratory, Florence University;4. Clinical Epidemiology and Biostatistics Unit, University Clinic Hospital of Santiago de Compostela, Institute of Sanitary Research of Santiago (IDIS),Santiago de Compostela |
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| Abstract: | Carbonic anhydrase (CA) IX is a hypoxia marker located almost exclusively in tumor cells. We analyzed the expression of this marker in dysplastic lesions adjacent to the surgical resection margin in patients with oral squamous cell carcinoma. We investigated 70 archived tumors, 36 of which showed dysplasia adjacent to the surgical margin. We used tissue microarray technology to perform an immunohistochemical study of CA IX expression. We found 12 (33.3%) cases of mild dysplasia (10 negative, 2 positive for CA IX), five (13.9%) cases of moderate dysplasia (3 negative, 2 positive for CA IX), 1 (2.8%) case of severe dysplasia (negative for CA IX) and 18 (50%) cases of carcinoma in situ (10 negative, 8 positive for CA IX). In cases of intense expression of CA IX in the tumor, the same distribution of positive and negative cases was observed in all degrees of dysplasia (mild, moderate, severe), although cases of carcinoma in situ tended to be CA IX positive. |
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| Keywords: | CA IX carbonic anhydrases dysplasia oral squamous cell carcinoma tissue microarray |
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