Effects of prostaglandin A2 on Na+, K+-ATPase activity in basolateral plasma membrane of rat intestine in vitro |
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Authors: | R Matsukawa N Terao M Hayakawa H Takiguchi |
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Affiliation: | Department of Biochemistry, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-Nishi, Matsudo, Chiba 271 Japan |
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Abstract: | Prostagladin A2, which prevents intestinal ulcers produced by administration of nonsteroidal antiinflammatory compounds such as indomethacin, inhibited the Na+,K+-ATPase activity in basolateral plasma membrane of rat intestine significantly. Prostaglandin A2 inhibited mainly the Na+-dependent phosphorylation step in the overall reaction of Na+,K+-ATPase. This decrease of the Na+,K+-ATPase activity by prostaglandin A2 was due to the decrease of Vmax of the enzyme and of the affinity of the enzyme for Na+. It was also suggested that the presence of both Δ5,6 and Δ10,11 structure of prostaglandin A2 may be necessary for the inhibition of the Na+,K+-ATPase activity. |
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Keywords: | PGs Prostaglandins |
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