Presence of immunoreactive endothelin in human milk |
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Authors: | H C Lam K Takahashi M A Ghatei S R Bloom |
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Affiliation: | Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England. |
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Abstract: | Endothelin-like immunoreactivity was detected in human milk at a concentration of 6.8 +/- 1.6 pmol/l (mean +/- SEM; n = 16) using a highly sensitive radioimmunoassay. Gel filtration and fast protein liquid chromatography (FPLC) verified the identity of the endothelin. FPLC revealed 4 peaks, one eluting just after the void volume, and the other three in the positions of endothelin-1, -2, and -3, respectively. |
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