Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides |
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| Authors: | Gurvich V Kim H Y Hodge R P Harris C M Harris T M |
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| Affiliation: | Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA. |
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| Abstract: | Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59-72%. |
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