A deletion on Chromosome 4 cosegregates with the whirler deafness mutation: exclusion of Orm1 as a candidate |
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Authors: | Adam JW Paige Brent W Kiernan Anabel Varela Michael JC Rogers David Hughes Karen P Steel Steve DM Brown |
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Institution: | (1) MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Didcot, Oxon OX11 0RD, UK, GB;(2) MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK, GB |
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Abstract: | Whirler (wi) mice display profound deafness and a head-tossing and circling phenotype, showing an autosomal recessive mode of inheritance.
The wi mutation has been shown to map close to the Orm gene cluster on mouse Chromosome (Chr) 4. We have, therefore, investigated the Orm loci as candidates for the whirler gene. Detailed mapping and analysis of the Orm gene cluster in both normal and whirler mice indicates the presence of a <48-kb deletion in whirler mice that disrupts the
Orm1 locus. The Orm1 locus is also deleted in the CE/J mouse strain, and we discuss the candidature of Orm1 for the whirler gene.
Received: 22 June 1999 / Accepted: 17 September 1999 |
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