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Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
Authors:Peng Deng  Quan Yuan  Yingduan Cheng  Jiong Li  Zhenqing Liu  Yan Liu  Ye Li  Trent Su  Jing Wang  Mari Ekimyan Salvo  Weiguang Wang  Guoping Fan  Karen Lyons  Bo Yu  Cun-Yu Wang
Institution:1. Laboratory of Molecular Signaling, Division of Oral Biology and Medicine, School of Dentistry, UCLA, Los Angeles, CA 90095, USA;2. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA;3. Institute for Quantitative and Computational Biology and Department of Biological Chemistry, UCLA, Los Angeles, CA 90095, USA;4. Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095, USA;5. Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA;6. Division of Constitutive and Regenerative Science, School of Dentistry, UCLA, Los Angeles, CA 90095, USA;7. Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, UCLA, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:skeletal aging  bone metabolism  bone marrow adiposity  mesenchymal stromal cells  mesenchymal stem cells  stem cell self-renewal  senescence-associated heterochromatin foci  parathyroid hormone  osteoporosis
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