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ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
Authors:Cheng Wang  Mingzi Zhang  Gustavo Garcia  E. Tian  Qi Cui  Xianwei Chen  Guihua Sun  Jinhui Wang  Vaithilingaraja Arumugaswami  Yanhong Shi
Affiliation:1. Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;2. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA;3. Department of Diabetes Complications & Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;4. Integrative Genomics Core, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA;5. Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA
Abstract:
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  • Keywords:ApoE  Alzheimer's disease  COVID-19  induced pluripotent stem cells  iPSCs  neurons  astrocytes  neuron-astrocyte co-culture  brain organoids  SARS-CoV-2 neurotropism  remdesivir
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