Low prevalence and independent prognostic role of del(11q) in Chinese patients with chronic lymphocytic leukemia |
| |
Authors: | Yi-Xin Zou Han-Ning Tang Jing Zhang Xiao-Lu Tang Shu-Chao Qin Yi Xia Hua-Yuan Zhu Chun Qiao Li Wang Lei Fan Wei Xu Jian-Yong Li Yi Miao |
| |
Institution: | 1. Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China;2. Key Laboratory of Hematology of Nanjing Medical University, Nanjing 210029, China;3. Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing 210029, China;4. Pukou CLL Center, Nanjing 210000, China |
| |
Abstract: | The 11q deletion (del(11q)) is a conventional cytogenetic aberration observed in chronic lymphocytic leukemia (CLL) patients. However, the prevalence and the prognostic value of del(11q) are still controversial. In this research, we retrospectively explored the prevalence, association, and prognostic significance of del(11q) in 352 untreated and 99 relapsed/refractory Chinese CLL patients. Totally 11.4% of untreated and 19.2% of relapsed/refractory patients harbored del(11q). Del(11q) was more common in patients with β2-microglobulin > 3.5 mg/L, positive CD38, positive zeta-chain associated protein kinase 70, unmutated immunoglobulin heavy variable-region gene and ataxia telangiectasia mutated mutation. Kaplan-Meier method and univariate Cox regression indicated that del(11q) was an independent prognostic factor for overall survival (OS). Based on the results of univariate Cox regression analysis, two nomograms that included del(11q) were established to predict survival. Desirable area under curve of receiver operating characteristic curves was obtained in the training and validation cohorts. In addition, the calibration curves for the probability of survival showed good agreement between the prediction by nomogram and actual observation. In summary, the prevalence of del(11q) is relatively low in our cohort and del(11q) is an unfavorable prognostic factor for untreated CLL patients. Besides, these two nomograms could be used to accurately predict the prognosis of untreated CLL patients. |
| |
Keywords: | Chronic lymphocytic leukemia 11q deletion Prognosis Nomogram |
本文献已被 ScienceDirect 等数据库收录! |
|