| 高抗菌活性乳酸菌拮抗食源性致病菌的研究进展 |
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| 引用本文： | 李海新,寇秀颖,谢新强,张菊梅,吴清平. 高抗菌活性乳酸菌拮抗食源性致病菌的研究进展[J]. 微生物学报, 2022, 62(10): 3732-3740 |
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| 作者姓名： | 李海新 寇秀颖 谢新强 张菊梅 吴清平 |
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| 作者单位： | 广东省科学院微生物研究所, 华南应用微生物国家重点实验室, 广东省微生物安全与健康重点实验室, 农业农村部农业微生物组学与精准应用重点实验室, 广东 广州 510070;华南理工大学生物科学与工程学院, 广东 广州 510006;无限极(中国)有限公司, 广东 广州 510405 |
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| 基金项目： | 国家自然科学基金(21977020);广东省重点实验室(2020B121201009);广东省科学院创新发展专项(2020GDASYL-20200401002) |
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| 摘 要： | 食源性致病菌严重威胁人类的生命健康。服用抗生素是目前最有效的治疗手段。但不规范使用抗生素,导致耐药性细菌日趋普遍。乳酸菌是公认的食品级安全微生物,因其具有拮抗致病菌、增强免疫功能、加强肠道屏障、平衡肠道菌群等功能而具有良好的应用前景,有望成为下一代安全、稳定、经济的生物抗菌剂,以减少甚至替代抗生素的使用。本文通过阐述乳酸菌抗菌物质、抗菌机制及抗菌功能特性等,以促进乳酸菌的研究和应用。
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| 关 键 词： | 乳酸菌 食源性致病菌 抗菌机制 抗菌物质 |
| 收稿时间： | 2022-03-02 |
| 修稿时间： | 2022-03-30 |
High antibacterial activity of lactic acid bacteria against food-borne pathogens |
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| LI Haixin,KOU Xiuying,XIE Xinqiang,ZHANG Jumei,WU Qingping. High antibacterial activity of lactic acid bacteria against food-borne pathogens[J]. Acta microbiologica Sinica, 2022, 62(10): 3732-3740 |
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| Authors: | LI Haixin KOU Xiuying XIE Xinqiang ZHANG Jumei WU Qingping |
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| Affiliation: | State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application, Ministry of Agriculture and Rural Affairs, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, Guangdong, China;School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China;Infinitus (China) Co., Ltd., Guangzhou 510405, Guangdong, China |
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| Abstract: | Food-borne pathogens threaten human life and health and antibiotics are the most effective choice at the moment.However,the irregular use of antibiotics has led to the rising prevalence of drug-resistant bacteria.Lactic acid bacteria are recognized as safe food-grade microorganisms.They boast good application prospects attributing to the functions of antagonizing pathogenic bacteria,improving immune regulation,strengthening intestinal barrier,and balancing intestinal microbiota.They are expected to become the next generation of safe,stable,and economical biological antibacterials to reduce or even replace antibiotics.This article describes the antibacterial substances,antibacterial mechanisms,and antibacterial functional properties of lactic acid bacteria to promote the research on and application of them. |
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| Keywords: | lactic acid bacteria food-borne pathogens antibacterial mechanism antibacterial substance |
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