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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization
Authors:Naoya Takayama  Alex Murison  Shin-ichiro Takayanagi  Christopher Arlidge  Stanley Zhou  Laura Garcia-Prat  Michelle Chan-Seng-Yue  Sasan Zandi  Olga I Gan  Héléna Boutzen  Kerstin B Kaufmann  Aaron Trotman-Grant  Erwin Schoof  Ken Kron  Noelia Díaz  John JY Lee  Tiago Medina  Daniel D De Carvalho  Mathieu Lupien
Institution:1. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada;2. Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan;3. Cell Therapy Project, R&D Division, Kirin Holdings Company, Limited, Kanagawa 236-0004, Japan;4. Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada;5. Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada;6. Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada;7. The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;8. Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;9. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1X8, Canada;10. Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada;11. Max Planck Institute for Molecular Biomedicine, Munster 48149, Germany
Abstract:
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  • Keywords:hematopoiesis  epigenetics  CTCF  chromatin interactions  chromatin accessibility  topologically associated domain  low-C  4D nucleome  single-cell ATAC-seq  hematopoietic stem cells
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