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Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use
Authors:Tae Wan Kim  Jinghua Piao  So Yeon Koo  Sonja Kriks  Sun Young Chung  Doron Betel  Nicholas D. Socci  Se Joon Choi  Susan Zabierowski  Brittany N. Dubose  Ellen J. Hill  Eugene V. Mosharov  Stefan Irion  Mark J. Tomishima  Viviane Tabar  Lorenz Studer
Affiliation:1. Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA;2. Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;3. Department of Neurosurgery and Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA;4. SKI Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA;5. Neuroscience Graduate Program of Weill Cornell Graduate School of Biomedical Sciences, Weill Cornell Medical College, New York, NY, USA;6. Institute for Computational Biomedicine, Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA;7. Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA;8. Department of Neurology, Columbia University Medical Center, New York, NY, USA;9. Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Abstract:
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  • Keywords:directed differentiation  human embryonic stem cells  human-induced pluripotent stem cells  neural patterning  WNT signaling  midbrain development  transplantation  Parkinson’s disease  cell therapy  preclinical study
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