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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition
Authors:Allison J Greaney  Tyler N Starr  Pavlo Gilchuk  Seth J Zost  Elad Binshtein  Andrea N Loes  Sarah K Hilton  John Huddleston  Rachel Eguia  Katharine HD Crawford  Adam S Dingens  Rachel S Nargi  Rachel E Sutton  Naveenchandra Suryadevara  Paul W Rothlauf  Zhuoming Liu  Sean PJ Whelan  Robert H Carnahan  Jesse D Bloom
Institution:1. Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA;2. Department of Genome Sciences & Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA;3. Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA;4. Howard Hughes Medical Institute, Seattle, WA 98109, USA;5. Molecular and Cell Biology, University of Washington, Seattle, WA 98195 USA;6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA;7. Program in Virology, Harvard Medical School, Boston, MA 02115, USA;8. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA;9. Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Abstract:
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  • Keywords:SARS-CoV-2  antibody escape  antigenic evolution  deep mutational scanning
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