首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease
Authors:James Brett Case  Rita E Chen  Longxing Cao  Baoling Ying  Emma S Winkler  Max Johnson  Inna Goreshnik  Minh N Pham  Swathi Shrihari  Natasha M Kafai  Adam L Bailey  Xuping Xie  Pei-Yong Shi  Rashmi Ravichandran  Lauren Carter  Lance Stewart  David Baker  Michael S Diamond
Institution:1. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA;2. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA;3. Department of Biochemistry, University of Washington, Seattle, WA 98195, USA;4. Institute for Protein Design, University of Washington, Seattle, WA 98195, USA;5. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA;6. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA;7. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA;8. Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA;9. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA;10. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA
Abstract:
><ol class=
  • Download : Download high-res image (185KB)
  • Download : Download full-size image
  • Keywords:SARS-CoV-2  COVID-19  pathogenesis  receptor-binding domain  miniprotein  variants  mice  prophylaxis  therapy  intranasal
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号