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BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors
Authors:Alexander A Mikryukov  Amine Mazine  Bei Wei  Donghe Yang  Yifei Miao  Mingxia Gu  Gordon M Keller
Institution:1. McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G1L7, Canada;2. Division of Cardiac Surgery, Department of Surgery, University of Toronto, Toronto, ON M5G1L7, Canada;3. Department of Genetics, Stanford University, Stanford, CA 94305, USA;4. Department of Pediatrics, Division of Pediatric Cardiology, Stanford School of Medicine, Stanford, CA 94305, USA;5. Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;6. Center for Stem Cell and Organoid Medicine, CuSTOM, Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA;7. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G1L7, Canada;8. Department of Medical Biophysics, University of Toronto, Toronto, ON M5G1L7, Canada
Abstract:
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  • Keywords:endocardium  endothelial cells  heart valves  coronary vasculature  human pluripotent stem cells  cardiac differentiation  trabecular myocardium  compact myocardium  BMP10  neuregulin
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