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3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
Authors:Kannan V Manian  Chad A Galloway  Sonal Dalvi  Anthony A Emanuel  Jared A Mereness  Whitney Black  Lauren Winschel  Celia Soto  Yiming Li  Yuanhui Song  William DeMaria  Akhilesh Kumar  Igor Slukvin  Michael P Schwartz  William L Murphy  Bela Anand-Apte  Mina Chung  Danielle SW Benoit  Ruchira Singh
Institution:1. Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA;2. Department of Biomedical Genetics, University of Rochester, Rochester, NY 14620, USA;3. Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14620, USA;4. Department of Biomedical Engineering, Robert B. Goergen Hall, University of Rochester, Rochester, NY 14627, USA;5. Department of Orthopedics and Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642, USA;6. Center for Oral Biology, University of Rochester, Rochester, NY 14642, USA;7. Department of Environmental Medicine, University of Rochester, Rochester, NY 14642 USA;8. Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA;9. Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53715, USA;10. NSF Center for Sustainable Nanotechnology, Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA;11. Department of Biomedical Engineering, University of Wisconsin, Madison, WI 53715, USA;12. Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, WI 53715, USA;13. Department of Ophthalmic Research, Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;14. Center for Visual Science, University of Rochester, Rochester, NY 14620, USA;15. UR Stem Cell and Regenerative Medicine Center, Rochester, NY 14620, USA;16. Materials Science Program, University of Rochester, Rochester, NY 14620, USA;17. Department of Chemical Engineering, University of Rochester, NY 14620, USA
Abstract:
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  • Keywords:retinal pigment epithelium  choriocapillaris  induced pluripotent stem cell  hydrogel  age-related macular degeneration  macular dystrophy  Sorsby's fundus dystrophy  tissue engineering  choroidal neovascularization
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