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Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids
Authors:Ling Huang  Ridhdhi Desai  Daniel N Conrad  Nayara C Leite  Dipikaa Akshinthala  Christine Maria Lim  Raul Gonzalez  Lakshmi B Muthuswamy  Zev Gartner  Senthil K Muthuswamy
Institution:1. Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;2. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;3. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA;4. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA;5. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA;6. Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA;7. NSF Center for Cellular Construction, San Francisco, CA 94158, USA
Abstract:
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  • Keywords:organoid  pancreatic cancer  KRAS  GNAS  acini  cancer precursor  pluripotent stem cell  plasticity  exocrine pancreas  lineage specification
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