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Early stem cell aging in the mature brain
Authors:Albina Ibrayeva  Maxwell Bay  Elbert Pu  David J. Jörg  Lei Peng  Heechul Jun  Naibo Zhang  Daniel Aaron  Congrui Lin  Galen Resler  Axel Hidalgo  Mi-Hyeon Jang  Benjamin D. Simons  Michael A. Bonaguidi
Affiliation:1. Eli and Edythe Broad Center for Regenerative Medicine & Stem Cell Research at USC, University of Southern California, Los Angeles, CA 90033, USA;2. Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA 90033, USA;3. USC Davis School - Buck Institute Graduate Program in the Biology of Aging, University of Southern California, Los Angeles, CA 90033, USA;4. Neuroscience Graduate Program, W. M. Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA;5. Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA;6. Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90033, USA;7. Davis School of Gerontology, University of Southern California, Los Angeles, CA 90033, USA;8. Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK;9. Gurdon Institute, University of Cambridge, Cambridge CB3 0HE, UK;10. Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Abstract:
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  • Keywords:stem cell  aging  adult neurogenesis  clonal analysis  quiescence  proliferation  cell fate  single cell RNA-seq  bioinformatics  Abl  Imatinib  intervention  hippocampus
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