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A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection
Authors:Hejun Liu  Meng Yuan  Deli Huang  Sandhya Bangaru  Fangzhu Zhao  Chang-Chun D. Lee  Linghang Peng  Shawn Barman  Xueyong Zhu  David Nemazee  Dennis R. Burton  Marit J. van Gils  Rogier W. Sanders  Hans-Christian Kornau  S. Momsen Reincke  Harald Prüss  Jakob Kreye  Nicholas C. Wu  Ian A. Wilson
Affiliation:1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA;3. Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam, the Netherlands;4. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA;5. German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany;6. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA;7. Neuroscience Research Center (NWFZ), Cluster NeuroCure, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany;8. Helmholtz Innovation Lab BaoBab, Berlin, Germany;9. Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany;10. Department of Pediatric Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Berlin, and Berlin Institute of Health, Berlin, Germany;11. Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;12. Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;13. Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA;14. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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  • Keywords:cross-neutralizing antibody  antibody cocktail  synergy  coronavirus  SARS-CoV-2  COVID-19  antibody-antigen interaction  3D structure  crystallography
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