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Effects of SGI-1027 on Formation and Elimination of PrPSc in Prion-Infected Cells |
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| Authors: | Li J J Ryou C S Kim D-H |
| Institution: | 1.Department of Chemistry, Gwangju Institute of Science and Technology, 61005, Gwangju, Republic of Korea ;2.Department of Pharmacy, Hanyang University, 15588, Ansan, Gyeonggi-do, Republic of Korea ;3.School of Undergraduate Studies, College of Transdisciplinary Studies, Daegu Gyeongbuk Institute of Science and Technology, 42988, Daegu, Republic of Korea ; |
| Abstract: | Molecular Biology - Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrPSc in prion-infected cells. Herein,... |
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