A model reaction demonstrating alkylating properties of pyridoxol, involving an o-quinone methide intermediate |
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| Authors: | M. Frater-Schrö der,M. Mahrer-Busato |
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| Affiliation: | Laboratory of Experimental and Toxicological Pathology, Institute of Pathological Anatomy, University Hospital, Zurich, Switzerland |
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| Abstract: | The synthesis of several specifically substituted pyridoxine derivatives 5, 6, 7, 8, 9, 10, 11, and 12, is described. A pyridoxol derived o-quinone methide, postulated as the common reaction intermediate, gives rise to the specific pyridoxol substitution encountered in these products. The mechanism is discussed as a model for a new type of pyridoxine transformation, either in known vitamin-B6-dependent enzymatic reactions or in toxicological reactions induced by pyridoxine. |
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| Keywords: | To whom correspondence may be addressed. |
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