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2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series |
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| Authors: | Navas Frank Bishop Michael J Garrison Deanna T Hodson Stephen J Speake Jason D Bigham Eric C Drewry David H Saussy David L Liacos James H Irving Paul E Gobel M Jeffrey |
| Affiliation: | Division of Chemistry, GlaxoSmithKline, 5Moore Drive, Research Triangle Park, NC 27709, USA. fn28689@gsk.com |
| Abstract: | A series of 2'-heteroaryl and 2'-oxime anilinomethylimidazolines was prepared and evaluated in in vitro functional assays for cloned human alpha1A, alpha1B, and alpha1D receptor subtypes. Potent and selective alpha1A agonists have been identified in these series. |
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