Proteins in action: the physics of structural fluctuations and conformational changes |
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Authors: | Parak Fritz G |
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Affiliation: | Physik - Department E17 der TUM, 85747, Garching, Germany. fritz.parak@ph.tum.de |
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Abstract: | Structural dynamics is essential for the biological function of proteins. Results from new experimental techniques should be compared with those from previous experiments in order to obtain a consistent picture of the physics of intramolecular fluctuations and conformational changes. The high intensity and time structure of synchrotron radiation have made possible time-resolved X-ray structure analysis and the determination of phonon density spectra through the Mössbauer effect. By combining results from Mössbauer absorption spectroscopy, incoherent neutron scattering, low-temperature crystallography and optical spectroscopy, a physical picture of protein dynamics emerges. |
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