| 树突状细胞和癌症的免疫学治疗 |
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| 引用本文： | 展德文,刘向昕,张兆山.树突状细胞和癌症的免疫学治疗[J].生物技术通讯,2004,15(6):604-606. |
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| 作者姓名： | 展德文 刘向昕 张兆山 |
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| 作者单位： | 军事医学科学院,生物工程研究所,北京,100071 |
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| 摘 要： | 树突状细胞(dendritc cells，DC)是一种抗原提呈细胞，能特异地引发和调控机体免疫。它具有抗原呈现功能而不损害免疫系统，不仅能够激活CD4^ 辅助T细胞和CD8^ 细胞毒性T细胞，还能活化B细胞和自然杀伤细胞。已有的研究让人们看到了癌症疫苗的希望，但还处于早期阶段，有许多尚未确定的因素。因此有关DC疫苗用于对肿瘤的保护性和治疗性免疫还有待于进一步的研究。
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| 关 键 词： | 树突状细胞 免疫学治疗 肿瘤 癌症疫苗 CD8^＋细胞 DC疫苗 辅助T细胞 早期阶段 调控 毒性 |
| 文章编号： | 1009-0002(2004)06-0604-03 |
| 修稿时间： | 2004年4月14日 |
Dendritic cells and immunotherapy for cancer |
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| ZHAN De-wen,LIU Xiang-xin,ZHANG Zhao-shanInstitute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China.Dendritic cells and immunotherapy for cancer[J].Letters in Biotechnology,2004,15(6):604-606. |
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| Authors: | ZHAN De-wen LIU Xiang-xin ZHANG Zhao-shanInstitute of Biotechnology Academy of Military Medical Sciences Beijing China |
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| Institution: | ZHAN De-wen,LIU Xiang-xin,ZHANG Zhao-shanInstitute of Biotechnology,Academy of Military Medical Sciences,Beijing 100071,China |
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| Abstract: | Dendritic cells(DC), nature's adjuvant, are antigen-presenting cells specialized to initiate and regulate immunity. Their potent antigen-presenting function has encouraged targeting of dendritic cells for harnessing the immune system against cancer. DC are efficient at activating not only CD4+ helper T-cells and CD8+ killer T-cells but also B-cells and innate effectors such as natural killer and natural killer T-cells. Early studies of adoptive transfer of tumor antigen-loaded DC have shown promise. However, DC vaccination is at an early stage, and several parameters still need to be established. The complexity of the DC system brings about the necessity for its rational manipulation for achieving protective and therapeutic immunity in patients. |
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| Keywords: | dendritic cells tumor vaccine immunotherapy antigen presentation |
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