Protective effects of zinc on cadmium toxicity in rodents |
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Authors: | C Claverie R Corbella D Martín C Díaz |
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Institution: | (1) Department of Analytical Chemistry, Nutrition and Food Science, University of La Laguna, 38074 Santa Cruz de Tenerife, Spain;(2) Department of Physical Medicine and Pharmacology, University of La Laguna, 38074 Santa Cruz de Tenerife, Spain |
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Abstract: | A study of acute and subacute toxicity of cadmium ions Cd(II)] was carried out on male Swiss mice and Sprague-Dawley rats
with and without previous administration of zinc chloride. The LD50 of Cd(II) as cadmium sulfate (ip) was lower in animals previously given 10 mg/kg of zinc(II) chloride (sc). Factors such
as animal weight variations, biochemical parameters, and accumulation patterns of Cd(II) and Zn(II) were taken into consideration
when the subacute toxicity was evaluated.
Alteration of the activities of glutamic pyruvic transaminase (GPT) and of glutamic oxaloacetic transaminase (GOT) was observed
in short-term-exposure (<6 h) cases. These alterations reverted to normal after 1 wk. The activity of alkaline phosphatase
(ALP) and the concentrations of cholesterol and triglycerides in serum are also changed, especially so in the groups given
CdSO4 alone. In the experimental groups treated with ZnCl2 prior to administration of cadmium, proteinuria was detected 5 wk after the treatment. Also at 5 wk, both Zn-treated and
nontreated groups showed an abnormally low liver mass with respect to total body mass. Both Cd and Zn are retained preferentially
in the liver but show also in the kidneys. If CdSO4 and ZnCl2 are given simultaneously, especially after 1 wk of treatment, Cd is accumulated in greater amounts in these organs when compared
to the groups given only cadmium sulfate. |
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Keywords: | Cadmium cadmium toxicity zinc zinc-protective effect accumulation factors biochemical parameters |
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