Lipase-catalysed acylation of prostanoids. |
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| Authors: | O Parve I J?rving I Martin A Metsala I Vallikivi M Aidnik T Pehk N Samel |
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| Institution: | Institute of Chemistry at Tallinn Technical University, Estonia. omar@boc.ic.ee |
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| Abstract: | Natural prostaglandins (PG) F2alpha and E1 as well as (+)-cloprostenol were regioselectively 11-acylated using Novozym 435 as a catalyst and vinyl acetate as an acyl donor. Unlike the above compounds the 15-OH group of PGE2 was also acylated with a significant velocity under the same conditions. The enantiospecificity of the lipase-catalysed 11-acetylation of cloprostenol was established by separate treatment of(+)- and (-)-cloprostenols. |
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