Extracorporeal shockwave-induced expression of lubricin in tendons and septa |
| |
| Authors: | Dafang Zhang Thomas Cheriyan Thomas M Schmid " target="_blank">Myron Spector |
| |
| Institution: | (1) Harvard Medical School, Boston, MA 02115, USA;(2) Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA;(3) Tissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA;(4) Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Boston, MA 02115, USA;(5) Department of Biochemistry, Rush University Medical Center, Chicago, IL 60612, USA;(6) VA Boston Healthcare System, Mail Stop: 151 Research, 150 S. Huntington Ave, Boston, MA 02130, USA; |
| |
| Abstract: | Lubricin, a lubricating glycoprotein that facilitates tendon gliding, is upregulated by mechanical as well as biochemical
stimuli, prompting this study of its induction by extracorporeal shockwave therapy (ESWT). The objective of this study was
to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model. Hindlimbs of six
rats were treated with low-dose ESWT and those of another six with high-dose ESWT, using contralateral limbs as controls.
After 4 days, resected samples were processed for immunolocalization of lubricin using a purified monoclonal antibody. ESWT
was found to increase lubricin expression in both low-dose and high-dose ESWT-treated tendons and also in septa. Lubricin
expression generally increased with increasing dose of ESWT. Increased lubricin expression may contribute to the beneficial
effects of ESWT in providing pain and symptom relief in musculoskeletal disorders by decreasing erosive wear. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
