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Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey
Authors:Ziver Sahin  Muge Bıcakcıgil  Kenan Aksu  Sevil Kamali  Servet Akar  Fatos Onen  Omer Karadag  Zeynep Ozbalkan  Askin Ates  Huseyin TE Ozer  Vuslat Yilmaz  Emire Seyahi  Mehmet A Ozturk  Ayse Cefle  Veli Cobankara  A Mesut Onat  Ercan Tunc  Nursen Düzgün  Sibel Z Aydin  Neslihan Yilmaz  İzzet Fresko  Yasar Karaaslan  Sedat Kiraz  Nurullah Akkoc  Murat Inanc  Gokhan Keser  F Aytul Uyar  Haner Direskeneli  Güher Saruhan-Direskeneli
Affiliation:1. Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, 34093, Capa Istanbul, Turkey
2. Department of Rheumatology, Yeditepe University, Faculty of Medicine, Ankara Cad No:102/104, Kozyatag?, 34752, Istanbul, Turkey
3. Department of Rheumatology, Ege University, Faculty of Medicine, Ankara Asfalti Uzeri, 35100, Bornova, Izmir, Turkey
4. Department of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, 34093, Capa, Istanbul, Turkey
5. Department of Rheumatology, Dokuz Eylül University, Faculty of Medicine, Dokuz Eylul Universitesi Sagl?k Yerleskesi, Inciralt?, 35340, Izmir, Turkey
6. Department of Rheumatology, Hacettepe University, Faculty of Medicine, 06100, Sihhiye, Ankara, Turkey
7. Department of Rheumatology, Ankara Numune Training and Research Hospital, Talatpasa Bulvar?, No:5, 06100, Alt?ndag, Ankara, Turkey
8. Department of Rheumatology, Cukurova University, Faculty of Medicine, Balcal?, 01330, Sar?cam, Adana, Turkey
9. Department of Rheumatology, Istanbul University, Cerrahpa?a Faculty of Medicine, Kocamustafapa?a Cad. No: 124, 34098, Cerrahpa?a, Istanbul, Turkey
10. Department of Rheumatology, Gazi University, Faculty of Medicine, 06500, Besevler, Ankara, Turkey
11. Department of Rheumatology, Kocaeli University, Faculty of Medicine, Eski ?stanbul Yolu, 41380, Umuttepe Yerle?kesi, Kocaeli, Turkey
12. Department of Rheumatology, Pamukkale University Faculty of Medicine, üniversite Caddesi K?n?kl?, 20020, Kampüsü, Denizli, Turkey
13. Department of Rheumatology, Gaziantep University, Faculty of Medicine, Sahinbey Ara?t?rma Hastanesi, 27310, Gaziantep, Turkey
14. Department of Rheumatology, Suleyman Demirel University, Faculty of Medicine, Do?u Kampüsü Morfoloji Binas?, Kat:2 32260, Isparta, Turkey
15. Department of Rheumatology, Ankara University, Faculty of Medicine, Morfoloji Yerle?kesi, S?hh?ye, 06100, Ankara, Turkey
16. Department of Rheumatology, Marmara University, Faculty of Medicine, Mimar Sinan Caddesi, No: 41, 34890, Pendik, Istanbul, Turkey
Abstract:

Introduction

HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors.

Methods

TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers.

Results

We found a significant association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B*52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78).

Conclusions

In this study, the previously reported association of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored further.
Keywords:
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