Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases |
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| Affiliation: | 1. Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China;2. Institute for Genome Engineered Animal Models of Human Diseases, National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning 116044, China;3. School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia;4. Department of Molecular Pathobiology, New York University College of Dentistry, New York 10010, USA;1. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, United States of America;2. Department of Chemistry, Vanderbilt University, Nashville, TN 37235, United States of America;3. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, United States of America;1. Pharmaceutics, Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare, 1714-1 Yoshino-machi, Nobeoka, Miyazaki 882-8508, Japan;2. Faculty of Pharmacy, Yasuda Women''s University, Hiroshima, Japan;3. Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan;4. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;1. School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand;2. Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Australia;3. School of Chemistry, University of Melbourne, Parkville, Australia;4. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA;5. Ferrier Research Institute, Victoria University of Wellington, Wellington, New Zealand;6. Bio21 Molecular Science & Biotechnology Institute, University of Melbourne, Parkville, Australia;1. Institute for Clinical Chemistry, University Hospital and University of Zürich, Zürich, Switzerland;2. Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, China;3. Institute for Biochemistry, University of Zürich; Zürich, Switzerland;4. National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, China;1. Department of Foundations of Medicine, NYU Long Island School of Medicine, Mineola, NY, USA;2. Department of Pediatrics, NYU Long Island School of Medicine, Mineola, New York, USA;3. Food Science Department, Rutgers Center for Lipid Research and Institute of Food Nutrition and Health, Rutgers University, New Brunswick, NJ, USA;4. Department of Obstetrics and Gynecology, NYU Long Island School of Medicine, Mineola, New York, USA |
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| Abstract: | Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases. |
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