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Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry
Institution:1. Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;2. Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA;3. Argonne National Laboratory, Lemont, IL, USA;4. The Institute of Cancer Research, London, UK;5. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA;6. Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK;7. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA;8. Department of Population Science, American Cancer Society, Atlanta, GA, USA;9. Institute of Biomedicine, University of Turku, Turku, Finland;10. Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia;11. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia;12. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland;13. Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK;14. University of Cambridge, Department of Oncology, Addenbrooke’s Hospital, Cambridge, UK;15. Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK;16. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;17. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark;18. Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia;19. Translational Research Institute, Brisbane, QLD, Australia;20. Australian Prostate Cancer Research Centre-Qld, Queensland University of Technology, Brisbane, QLD, Australia;21. Prostate Cancer Research Program, Monash University, Melbourne, VIC, Australia;22. Dame Roma Mitchell Cancer Centre, University of Adelaide, Adelaide, SA, Australia;23. Chris O''Brien Lifehouse and The Kinghorn Cancer Centre, Sydney, NSW, Australia;24. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden;25. University College London, Department of Applied Health Research, London, UK;26. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK;27. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK;28. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA;29. Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA;30. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA;31. Nuffield Department of Population Health, University of Oxford, Oxford, UK;32. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, MA, USA;33. SWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, WA, USA;34. Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada;35. Department of Surgery (Urology), University of Toronto, Toronto, ON, Canada;36. Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut national de la recherche scientifique, Laval, QC, Canada;37. Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada;38. Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA;39. Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;40. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;41. Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark;42. Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark;43. Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA;44. International Epidemiology Institute, Rockville, MD, USA;45. University of Ghana Medical School, Accra, Ghana;46. Korle Bu Teaching Hospital, Accra, Ghana;47. Centre for Biomarkers and Biotherapeutics, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, London, UK;48. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA;49. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA;50. Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK;51. Humangenetik Tuebingen, Tuebingen, Germany;52. Division of Urologic Surgery, Brigham and Women’s Hospital, Boston, MA, USA;53. CeRePP, Tenon Hospital, Paris, France;54. Sorbonne Universite, GRC 5 Predictive Onco-urology, Tenon Hospital, Paris, France;55. \"Exposome and Heredity\", CESP (UMR 1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France;56. Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA;57. Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA;58. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA;59. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway;60. Clinical Gerontology Unit, University of Cambridge, Cambridge, UK;61. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;62. Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain;63. Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain;64. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain;65. Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;66. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;67. Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal;68. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal;69. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;70. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;71. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA;72. ISGlobal, Barcelona, Spain;73. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;74. Universitat Pompeu Fabra (UPF), Barcelona, Spain;75. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;76. Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA;77. George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA;78. Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA;79. University Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France;80. Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria;81. Department of Urology, Cancer Therapy and Research Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA;82. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany;83. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany;84. Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany;85. Department of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA;86. Division of Health Equities, Department of Population Sciences, City of Hope, Duarte, CA, USA;87. Department of Urology, Northwestern University, Chicago, IL, USA;88. The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA;89. Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA;90. James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD, USA;91. Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, NY, USA;92. Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados;93. Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;94. Faculty of Health and Medical Sciences, The University of Surrey, Guildford, Surrey, UK;95. Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium;96. Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, USA;97. Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;98. Cancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia;99. Department of Urology, University of Washington, Seattle, WA, USA;100. Division of Epidemiology, Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA;101. Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI, USA;102. Department of Oncology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia;103. Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada;104. Division of Radiation Oncology, Cross Cancer Institute, Edmonton, AB, Canada;105. Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Leuven, Belgium;106. Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain;107. University of California San Diego, Moores Cancer Center, La Jolla, CA, USA;108. Genetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), Vigo (Pontevedra), Spain;109. Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK;110. The University of Surrey, Guildford, Surrey, UK;111. Case Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Cleveland, OH, USA;112. Center for Prostate Disease Research, Uniformed Services University, Bethesda, MD, USA;113. Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA;114. 109 Department of Urology, Erasmus University Medical Center, Cancer Institute, Rotterdam, the Netherlands;115. The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA;116. Division of Research, Kaiser Permanente, Northern California, Oakland, CA, USA;117. Department of Urology, University of California San Francisco, San Francisco, CA, USA;118. Department of Epidemiology and Population Health, Department of Biomedical Data Science, Stanford Cancer Institute, Stanford, CA, USA;119. The Institute of Cancer Research, Sutton, London, UK;120. Royal Marsden NHS Foundation Trust, London, UK;121. School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda;122. VA Boston Healthcare System, Boston, MA, USA;123. Department of Medicine, Harvard Medical School, Boston, MA, USA;124. Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA;125. VA Connecticut Healthcare System, West Haven, CT, USA;126. Yale School of Medicine, New Haven, CT, USA;1. Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;2. Harvard Medical School, Boston, MA, USA;1. Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland;2. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA;3. Clinicum, Department of Public Health, University of Helsinki, Helsinki, Finland;4. Department of Epidemiology and Public Health, University College London, London, UK;5. Broad Institute of MIT and Harvard, Cambridge, MA, USA;6. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA;1. Genetics Division, Universidade Federal de São Paulo, São Paulo, Brazil;2. Department of Computational Biology, University of Lausanne, Lausanne, Switzerland;3. Swiss Institute of Bioinformatics, Lausanne, Switzerland;4. University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland;5. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland;6. Sleep Institute, São Paulo, Brazil;7. Department of Clinical, Educational and Health Psychology, University College London, London, UK;1. Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;2. Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;3. Cancer Genomics Unit, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;4. NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;5. Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA;6. Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA;7. Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA;1. The Dalglish Family 22q Clinic for Adults, and Department of Psychiatry, University Health Network, Toronto, ON, Canada;2. Toronto General Research Institute and Division of Cardiology, Department of Medicine, University Health Network, Toronto, ON, Canada;3. Clinical Genetics Research Program and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada;4. Department of Psychiatry, University of Toronto, Toronto, ON, Canada;5. 22q and You Center, Clinical Genetics Center, and Section of Genetic Counseling, Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;6. Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA;7. Department of Human Biology and Medical Genetics, Sapienza University, Rome, Italy;8. Advisium, ’s Heeren Loo Zorggroep, Amersfoort, the Netherlands;9. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, the Netherlands;10. Department of Pediatric Rheumatology and Immunology, Queen Silvia Children’s Hospital, SahlgrenskaUniversity Hospital, Gothenburg, Sweden;11. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;12. Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada;13. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;1. Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA;2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA;3. Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA;4. VA Cooperative Studies Program Clinical Epidemiology Research Center (CSP-CERC), VA CT Healthcare System, West Haven, CT, USA;5. Department of Anthropology, University of Toronto, Mississauga, ON, Canada;6. Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;7. Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA;8. Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA;9. Department of Biostatistics and Bioinformatics, Duke University, Durham, NC 27705, USA;10. VA Cooperative Studies Program Epidemiology Center-Durham, Department of Veterans Affairs, Durham, NC 27705, USA;11. Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA;12. Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA
Abstract:
Keywords:polygenic risk score  prostate cancer  health disparities  genome-wide polygenic risk score  African ancestry  genetics  risk modeling
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