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Converting and hoarding driven by protein phosphorylation in Toxoplasma gondii
Affiliation:1. P6: Metabolism of Microbial Pathogens, Robert Koch Institute, 13353, Berlin, Germany;1. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Allschwil, Switzerland;2. University of Basel, Basel, Switzerland;1. Department of Integrative Biology, 501 Life Sciences West, Oklahoma State University, Stillwater, OK 74078, USA;1. Novartis Institute for Tropical Diseases, Emeryville, CA, USA;1. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA;2. University of Bern, Bern, Switzerland;1. Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, MIVEGEC (IRD 224-CNRS 5290-UM1-UM2), Institut de recherche pour le développement, BP 6450134394 Montpellier Cedex 5, France;1. Harvard T.H. Chan School of Public Health, Boston, MA, USA;2. Institut Pasteur, Paris, France
Abstract:Successful parasitism relies on the evasion of adversarial host responses. Wang et al. have recently shown that Toxoplasma gondii relies on the protein phosphatase 2A (PP2A) to cause persisting infections. The phosphatase controls the development of dormant parasite stages and the accumulation of sugar supplies.
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