Stem cell-derived exosomes in bone healing: focusing on their role in angiogenesis |
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| Institution: | 1. School of Management, Guangzhou University, Guangzhou, China;2. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia;3. Independent Researcher, India;4. Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia;5. Master''s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia;6. Dr Soetomo General Academic Hospital, Surabaya, Indonesia;7. Department of Physiology, Ferghana Medical Institute of Public Health, Ferghana, Uzbekistan;8. Department of Mathematics, Dwaraka Doss Goverdhan Doss Vaishnav College, University of Madras, Chennai, India;9. Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi Arabia;10. Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelshikh University, Kafrelshikh, Egypt;11. Al-Manara College for Medical Sciences, Maysan, Iraq;12. Department of Anesthesia Techniques, Al-Mustaqbal University College, Babylon, Iraq;13. Al-Nisour University College, Baghdad, Iraq;14. Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq;15. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia;1. Department of Cell Biology, Zunyi Medical University, Zunyi, Guizhou Province, China;2. Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;1. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;2. Center for Research and Application of Cellular Therapy, Kyoto University Hospital, Kyoto, Japan;3. Department of Hematology, Sakai City Medical Center, Osaka, Japan;4. Japanese Red Cross Kinki Block Blood Center, Osaka, Japan;5. Japanese Red Cross Blood Service Headquarters, Tokyo, Japan;1. Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas, USA;2. Department of Kinesiology and Health Education, University of Texas at Austin, Austin, Texas, USA |
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| Abstract: | Fractures in bone, a tissue critical in protecting other organs, affect patients’ quality of life and have a heavy economic burden on societies. Based on regenerative medicine and bone tissue engineering approaches, stem cells have become a promising and attractive strategy for repairing bone fractures via differentiation into bone-forming cells and production of favorable mediators. Recent evidence suggests that stem cell-derived exosomes could mediate the therapeutic effects of their counterpart cells and provide a cell-free therapeutic strategy in bone repair. Since bone is a highly vascularized tissue, coupling angiogenesis and osteogenesis is critical in bone fracture healing; thus, developing therapeutic strategies to promote angiogenesis will facilitate bone regeneration and healing. To this end, stem cell-derived exosomes with angiogenic potency have been developed to improve fracture healing. This review summarizes the effects of stem cell-derived exosomes on the repair of bone tissue, focusing on the angiogenesis process. |
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